SOLVED

21) There are two forms of COX activity. COX-1 regulates stomach mucin, protecting the stomach lining; COX-2 promotes inflammation, pain and fever. Newer anti-inflammatory drugs for arthritic patients would inhibit A) COX-1. B) COX-2. C) Both COX-1 and COX-2. D) Arachidonate synthesis. 22) Properties of aspirin may include A) inhibition of COX activity. B) increased production of prostaglandins. C) Both A and B. D) None of the above. 23) All of the following occur during synthesis of ether lipids except A) esterification of an acyl group from fatty acyl CoA to dihydroxyacetone phosphate. B) displacement of the fatty acid of 1-acyldihydroxyacetone phosphate by a fatty alcohol. C) oxidation of the keto group of 1-acyldihydroxyacetone by NADPH. D) esterification of 1-alkylglycero-3-phosphate to produce 1-alkyl-2-acylglycero-3-phosphate. 24) The pathway describing the formation of ether lipids in mammals begins with A) the citric acid cycle. B) pyruvic acid. C) dihydroxyacetone phosphate. D) choline. 25) Which sphingolipid is a precursor for all other types of sphingolipids? A) Sphingomyelin. B) Cerebroside. C) Ganglioside. D) Ceramide. 26) Lysosomal storage diseases occur when mutations cause defects in ________. A) sphingolipid biosynthesis enzymes B) sphingolipid degradation enzymes C) lysosome formation D) formation of N-acetylgalactosamine derivatives 27) Which of the following is a true statement, concerning HMG-CoA reductase? A) It is regulated by covalent modification of a serine in its active site. B) It catalyzes the first committed step in cholesterol biosynthesis. C) It causes the production of NADPH. D) The product of the reaction it catalyzes is acetoacetyl CoA. 28) Cholesterol is a precursor for each of the following, except A) bile salts. B) vitamin D. C) testosterone. D) vitamin C. 29) Drugs called statins lower cholesterol levels because they ________. A) degrade HMG-CoA reductase B) bind serum cholesterol C) inhibit HMG-CoA reductase D) bind bile salts 30) Which of the following is mismatched? A) Bile salts – intestinal absorption of lipids. B) B-estradiol – sex characteristics. C) Cholesterol – membrane fluidity. D) Squalene – lipid vitamin.